Vi tog i dagarna upp lite om TRP och TRPV som vi kan se är TRPV ganska nära förknippade med calcium men även med annexin II / S100A10, calmodulin och PI3 kinase. Vilket kanske visar lite mer om the stairway to TRPV.

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Carbon Disulfide – CS2 Intro

Hypo thesis: The Etiology of Schizophrenia 1

Hypo thesis: The Etiology of Schizophrenia II

The pathomorphology of CS2 neuropathy resembles much like other samples orginating from an impaired energy metabolism. (1) A studie in rats shows the oxidative effects of CS2 exposure, a marked increase in cerebral cortex hippocampus, spinal cord and serum. Reactive oxygen species, Malondialdehyd. Ca2+ and Calmodulin levels increased in in Cerebral Cortex, hippocampus and spinal cord. (2) Carbon disulfide is used in viscose rayon plants as a solvent in the spinning process. It is known to have central and peripheral neurotoxic effects, and among the pleiotrophic conditions it causes are atherosclerotic change, diabetes mellitus, and coronary heart disease (3-6). In previous studies, the radiologic findings of carbon disulfide poisoning were diffuse or focal brain atrophy, infarcts in the basal ganglia, subcortial white matter and gray matter, and central demyelination (7-11). A few case reports have described the computed tomographic (CT) (7-10) or magnetic resonance imaging (MRI) findings (10, 11 )